In 1986 I had the privilege to begin a long collaboration with the Giovanni Lorenzini Medical Foundation. During more than three decades of working with the Foundation I was privy to some of the most important work being done globally in translational medicine. The meetings orchestrated by the Lorenzini Foundation brought together some of the greatest minds in the interdisciplinary fields of non-communicable diseases (NCD), specifically as seen in the series of DALM symposia. This success places the Lorenzini Foundation as a leader in the discussion and dissemination of some of the most important scientific and medical advances today and it will inform and shape the health and well-being of our society tomorrow.

Antonio M. Gotto, Jr.
Dean Emeritus, Weill Cornell Medical College Provost for Medical Affairs Emeritus, Cornell University

HPV (2010 – Ongoing)

The Lorenzini Foundation’s work on the understanding of the mechanisms of inflammation and the links between some viral infections and cancer is well known. As a result of the increasing evidence of the direct relationship between some viruses and the onset of some cancers, in females and in males, linked not only to the sexual organs (and of pre-neoplastic lesions in both sexes), the Foundation has been committed to increasing the awareness of, and support to, decision makers in developing policies in favor of eradication of human papillomavirus (HPV).

Furthermore, the work of the Foundation has been directly credited as being one of the first organizations to actively promote the focus on the vaccination efforts towards males since they may be considered the transmitters of the virus.

This new focus on the prevention of the spread of the virus, through vaccination in young people, and thus the disease risks for these cancers, has contributed greatly to the understanding and prevention of these types of cancers.

Women’s Health and Menopause (1995 – 2004), and Gender Medicine ongoing

Women’s health and menopause has been an expanding field of medical practice and scientific investigation in the past decade. Today, most women live long enough to become postmenopausal. After many years of international and multidisciplinary panels and conferences in this area, the Foundation’s work made history when it coordinated a monumental publication monograph, based on extensive international review and evaluation of the scientific evidence. The International Position Paper on Women’s Health and Menopause, published by the NIH is the culmination of this work. It was the representation of 7 years of cooperation between the National Heart, Lung, and Blood Institute (NHLBI) and the Giovanni Lorenzini Medical Science Foundation (Milan, Italy and Houston, TX) in a public/private partnership in the development and co-sponsorship of four international conferences on Women’s Health and Menopause since the mid-1990s. The first three conferences were held in Italy, and the later ones were held in Washington, DC. The last two conferences were also co-sponsored by the Office of Research on Women’s Health (ORWH), National Institutes of Health (NIH).
The work done in this area brought to the forefront, for the first time, the importance of looking at women’s health issues from an interdisciplinary perspective where, not only cancer and osteoporosis, in women, but also other health problems, such as cardiovascular disease and Alzheimer’s disease, were also considered in looking at the total patient.

Very importantly, this work informed about the misleading knowledge, up until then, of the use of hormone replacement therapy and the potential negative impact that such therapies posed.

This activity also represents an effective basis for the study and evaluation of gender differences, including gender, age, ethnic and geographic areas.

Prostaglandins (1975 – 2000)

For over 25 years, the Lorenzini Foundation designed and orchestrated a series of medical congresses and meetings for basic scientists and clinicians working on the biomedical research in prostaglandins and related compounds. Much of the research presented for the first time at the Foundation congresses starting in 1975 under the chairmanship of Bengt Samuelsson, led to his being awarded the Nobel Prize in physiology and medicine, in 1982, together with John Vane and Sune Bergstrom, for their research on prostaglandins. The Proceedings of this groundbreaking series of meetings, known as the Blue Book series, represent the culmination of this great body of work.

DALM Series (1960 – 2011, and ongoing)

For many years, the Lorenzini Foundation designed and presented another series of Congresses with the highest of recognized value – Drugs Affecting Lipid Metabolism or DALM. These meetings were held jointly in the USA and Italy since 1960 and has brought together some of the most important international experts in the interdisciplinary field of cardiometabolic diseases. The success of these symposia firmly placed the Lorenzini Foundation as an organization at the forefront of the most significant scientific and medical advances of the last 30 years, including most recently the interest in diagnosis and treatment of familial hypercholesterolemia.

The focus of the Foundation extends far beyond the traditional realm of biomedical and clinical research and practice into that of health economics and sustainability.